Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease
نویسندگان
چکیده
The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.
منابع مشابه
Vitamin D deficiency in children with Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and factors affecting response to cholecalciferol therapy: A quasi-experimental study from low-middle income setting
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children. Methods: This quasi-experimental st...
متن کاملFGF23 and mineral metabolism, implications in CKD-MBD.
Correspondence: Mariano Rodríguez Servicio de Nefrología. Hospital Universitario Reina Sofía. REDINREN, IM IBIC, Córdoba. [email protected] The regulation of mineral metabolism is achieved trough a complex interaction of hormonal factors and target organs. Before the discovery of FGF23 we believed that the regulation of serum calcium and phosphate was mainly the result of...
متن کاملVitamin D deficiency and stroke
Vitamin D comprises a group of fat-soluble pro-hormones, obtained from sun exposure, food, and supplements, and it must undergo two hydroxylation reactions to be activated in the body. Several studies have shown the role of vitamin D in mineral metabolism regulation, especially calcium, phosphorus, and bone metabolism. Some factors such as inadequate vitamin intake and liver or kidney disorders...
متن کاملApplicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients
BACKGROUND Elderly patients with chronic kidney disease (CKD) are usually at a high risk of fractures due to both osteoporosis and CKD-mineral bone disease (MBD). A new marker is needed to prevent fractures and control CKD-MBD from the early to advanced stages of CKD. In the early stage of CKD, fibroblast growth factor 23 (FGF23) level increases before parathyroid hormone (PTH) and phosphate le...
متن کاملPathogenesis and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder
The prevalence of chronic kidney disease (CKD) is increasing, and CKD patients are at risk for severe adverse outcomes such as progressive loss of kidney function, cardiovascular (CV) disease, and premature death [1]. CKD-Mineral and Bone Disorder (CKD-MBD) is the clinical syndrome that develops as a systemic disorder of bone and mineral metabolism due to CKD, which is manifested by abnormaliti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2013